Evènement pour le groupe BioInformatique et Visualisation
|Date|| 2014-11-13 11:00-12:00|
|Titre||Semantic Zooming and Navigation in Metabolic Networks |
|Résumé||The complexity of genome-scale metabolic models makes them quite difficult for human users to read, since they contain thousands of reactions that must be included for accurate computer simulation. For example, the metabolic network of the bacterium E. coli contains 2 168 reactions, the yeast 7 metabolic network model of S. cerevisiae includes 2 352 reactions, and recon 2, a global human metabolism reconstruction, has 7 440 reactions. Interestingly, hidden similarities between groups of reactions can be discovered, and generalized to reveal higher-level patterns.
The web-based navigation system Mimoza allows a human expert to explore metabolic network models in a semantically zoomable manner: The most general view represents the compartments of the model; the next view shows the generalized versions of reactions and metabolites in each compartment; and the most detailed view represents the initial network with the generalization-based layout (where similar metabolites and reactions are placed next to each other). It allows a human expert to grasp the general structure of the network and analyze it in a top-down manner. |
|Lieu||salle 178, LaBRI |
|Orateur||Anna Zhukova |
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