Evènement pour le groupe BioInformatique et Visualisation


Date 2010-12-02  11:00-12:30
TitreA new method to analyze flux distributions in metabolic networks, application to Trypanosoma brucei 
RésuméWe present a new method that both address flux analysis and model validation for metabolic networks. To reach biological reality, our method integrates heterogeneous available data. The structural complexity of metabolic networks can lead to alternatives fluxes that can be formulated as a complex optimization problem. The traditional framework, Flux balance analysis (FBA) by focusing on a single constraint to optimize, does not allow the incorporation of multipurpose experimental data. To address this problem, we propose a method that takes additional constraints for increasing biological assumptions in a multiobjective function. In such analysis, the complexity of the underlying problems involves the use of meta-heuristics. We have implemented this method in "Metaboflux", and applied it to the Trypanosoma brucei energetic metabolism to determine fluxes in each individual glycosomal branches compatible with biological observations. 
Lieu178 (LaBRI) 
OrateurAmine Ghozlane 
Emailamine.ghozlane@labri.fr 
UrlLaBRI 



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