Meanie Prague’s seminar, Inria BSO. Title of her presentation: "Use of mechanistic models to evaluate the effect of SARS-CoV-2 vaccines"
We will illustrate how research in biostatistics on non-linear mixed effects models can accelerate the development of vaccines. After a short introduction on what is a mechanistic model, we will illustrate how this type of modeling can be used to identify correlates of protection in the context of SARS-CoV-2. We will finish by a discussion on how within-host models of vaccine efficacy can help informing between-host models of infectious diseases spread.